Age-related changes in responsiveness of rat Leydig cells to hCG

Age-related changes in the expression of 11beta-hydroxysteroid dehydrogenase type 2 in rat Leydig cells.

Previous studies in rats have shown that the ability of Leydig cells (LCs) to produce testosterone significantly declines with age. To address the possible mechanisms by which aging LCs lose their steroidogenic function, we determined the effect of aging on the expression of 11beta-hydroxysteroid dehydrogenase (11beta-HSD) type 2. The enzyme plays a protective role in blunting the suppressive e...

Age-related changes in microvillar cells of rat olfactory epithelium.

The nature and function of microvillar cells (MVCs) of the mammalian olfactory epithelium (OE) are little understood. Previous studies have examined MVC morphology in the developing and mature OE, but not in the aged OE. The present study investigated the effect of aging on MVCs of the OE in male Sprague-Dawley rats using histological and immunohistochemical methods. OE of aged rats contained M...

P-4: Adverse Effects Associated with PersistentStimulation of Leydig Cells with hCG In vitro

Background: The detrimental effects of persistent stimulation with hCG were investigated in rat Leydig cells in vitro. Materials and Methods: Oxidative stress parameters such as lipid peroxidation, Reactive oxygen species(ROS), Total antioxidant capcity (TAC) and activities of antioxidant enzymes were assessed in the treated cells. Apoptosis amongest the trearted cells were detected by in situ ...

Age-dependent changes in rat testicular LH/hCG receptors in relation to the membrane fluidity.

Age-related changes in rat retina.

PURPOSE To describe the changes in rat retina occurring with ageing by means of histological methods, scanning electron microscopic observations and morphometrical data; and to study by means of biochemical methods the amount of protein content in retinal tissues. METHODS Samples of fresh retinal tissue obtained from young, adult, and aged rats were studied by means of traditional histologica...